We are interested in understanding how dendrites and their integrative properties contribute to learning and memory functions. Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks). We then use the models to study how the anatomical, biophysical and plasticity properties of dendrites contribute to memory functions.

Our lab has recently expanded its research activities to include experiments in mice. Using head-fixed behavioral set-ups, in vivo imaging and electrophysiology, our primary goal is to probe dendritic contributions to neuronal and circuit computations as well as behavior. Current projects focus on the role of dendritic nonlinearities in the prefrontal cortex and the animal’s ability to exhibit behavioral flexibility.