We’re excited to share our latest collaborative study with the Losonczy Lab and Polleux Lab, led by Simone Tasciotti, that is now available on bioRxiv!
🔍 In this work, we tackle a central question in neuroscience: how do hippocampal neurons become selective for specific spatial locations?
📌 Using hyperdetailed reconstructions of individual CA1 pyramidal neurons, we reveal how the spatial distribution and clustering of synapses shapes place field selectivity.
💡 Our computational models show:
- Co-tuned, spatially clustered excitatory inputs support robust spatial tuning 🧭
- Randomized synaptic arrangements disrupt tuning 🧠❌
- Clustering has distinct effects on apical vs. basal dendrites 🌿
These findings highlight the intricate relationship between synaptic architecture and neuronal computation in the hippocampus.
📄 Read the full preprint here.
