Welcome to the website of the Computational Biology Lab

About our research

Computational Neuroscience Projects

We are interested in understanding how dendrites and their integrative properties contribute to learning and memory functions. Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks). We then use the models to study how the anatomical, biophysical and plasticity properties of dendrites contribute to memory functions.

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Bioinformatics Projects

We focus on developing computational methods and tools for (a) analyzing large-scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks. Our methodological approaches include (a) novel clustering and feature selection algorithms, (b) machine learning algorithms such as artificial neural networks, hidden Markov models etc.

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Outreach

Συνενέντευξη της Δρ. Ποϊράζη στο protagon.gr σχετικά με την έρευνα που διεξάγεται στο εργαστήριο, με ειδικό αφιέρωμα στα αποτελέσματα της πρόσφατης συνεργασίας με το εργαστήριο του Dr. Losonczy στο Πανεπιστήμιο του Columbia.

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Latest News

Dr. Poirazi receives the Friedrich Wilhelm Bessel Research Award from the Alexander von Humboldt Foundation.

Dr. Poirazi receives the Friedrich Wilhelm Bessel Research Award by Hans-Christian Paper, president of the Alexander von Humboldt Foundation. The ceremony took place during the 47th Symposium for Research Award Winners of the Alexander von Humboldt Foundation in Bamberg, Germany March 28th-30th 2019.

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IMBB-FORTH and Columbia University researchers pinpoint the neurons that control brain's memory flow

The laboratories of Dr. Losonczy at Columbia University in New York, and ours, Dr. Poirazi at the Institute of Molecular Biology and Biotechnology (IMBB) of FORTH, joined forces in order to explain how neurons flexibly lay down or recall memories. The study, which was recently published in Neuron, is the first to provide visual evidence that a particular ...

 

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Dr. Papoutsi awarded with the prestigious NARSAD 2018 Young Investigator Grant

"Athanasia Papoutsi, Ph.D., will be taking a closer look at the cells in the prefrontal cortex of the brain to determine whether modifications of the “spines” in single neurons ... ". Read the full announcement. 

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Successful completion of DENDRITES 2018 EMBO meeting

The 3rd EMBO Workshop on Dendrites was completed with great success...

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Funding