Welcome to the website of the Computational Biology Lab

Panayiota Poirazi is the chair of the FENS-Kavli network of excellence
FENS-Kavli’s vision is to shape the future of Neuroscience by putting young researchers in the driver’s seat. We aim to improve Neuroscience in Europe through providing opportunities for young scientists, influencing science policy, and facilitating the exchange between science and society.

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About our research

Research in the CBL can be divided in two disciplines: (a) computational neuroscience, where we focus on the use of modeling techniques for characterizing the role of dendrites in learning and memory and (b) bioinformatics, where we focus on the development of methods and tools for analyzing and modeling biological data.

Computational Neuroscience Projects

We are interested in understanding how dendrites and their integrative properties contribute to learning and memory functions. Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks). We then use the models to study how the anatomical, biophysical and plasticity properties of dendrites contribute to memory functions.

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Bioinformatics Projects

We focus on developing computational methods and tools for (a) analyzing large-scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks. Our methodological approaches include (a) novel clustering and feature selection algorithms, (b) machine learning algorithms such as artificial neural networks, hidden Markov models etc.

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Latest News

We announce additional support from EMBO for the DENDRITES 2016 EMBO Workshop

We are happy to announce additional support from EMBO for the DENDRITES 2016 EMBO Workshop. As a result...

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Collaboration with Matthew Larkum through a NeuroCure Visiting Fellowship

We are excited to announce that Dr. Poirazi has been appointed a NeuroCure Visiting Fellow at the Charité University of Berlin as of April 1st 2016. The NeuroCure is a Cluster of Excellence in the neurosciences at the Charité ? Universitätsmedizin Berlin and its partners are the Humboldt-Universität zu Berlin, Freie Universität Berlin, Max-Delbrück Center for Molecular Medicine (MDC), Leibniz-Institut für Molekulare Pharmakologie (FMP) and German Rheumatism Research Centre Berlin (DRFZ).

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HSN travel fellowship to Alexandra Tzilivaki

Congratulations to Alexandra Tzilivaki for being awarded a travel grant by the Hellenic Society for Neuroscience in order to present her work at the FENS Forum 2016, the largest Neuroscience meeting in Europe!

 

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Funding