"This study is remarkable in that it links microscale remodeling of dendritic spine architecture to behavioral performance in adult mice, outside of the developmentally relevant critical period. The results pave the way for interesting future questions to address ..."read more...
Welcome to the website of the Computational Biology Lab
About our research
Computational Neuroscience Projects
We are interested in understanding how dendrites and their integrative properties contribute to learning and memory functions. Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks). We then use the models to study how the anatomical, biophysical and plasticity properties of dendrites contribute to memory functions.read more...
We focus on developing computational methods and tools for (a) analyzing large-scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks. Our methodological approaches include (a) novel clustering and feature selection algorithms, (b) machine learning algorithms such as artificial neural networks, hidden Markov models etc.read more...
WEF ERC IdeasLab 2014
Our publication in Nature Communications is recommended by F1000 for its special significance in the field
The laboratory of Dr. Alcino Silva at the University of California Los Angeles joined forces with the lab of Dr. Poirazi at IMBB-FORTH in order to explain why the "banding together" of synapses in dendrites relates to better learning and memory. The work is published in the scientific journal Nature Communications, and is likely to have important implications for memory-related dysfunctions.
Dr. Poirazi joins 65 other outstanding researchers who have been newly-elected to the organisation which promotes excellence in the life sciences. There are currently 1700 EMBO members and more than 59 Nobel laureates amongst the membership.