About our research

Computational Neuroscience

We are interested in understanding how dendrites and their integrative properties contribute to learning and memory functions. Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks). We then use the models to study how the anatomical, biophysical and plasticity properties of dendrites contribute to memory functions.

 

read more ...

Experimental Neuroscience

Our lab has recently expanded its research activities to include experiments in mice. Using head-fixed behavioral set-ups, in vivo imaging and electrophysiology, our primary goal is to probe dendritic contributions to neuronal and circuit computations as well as behavior. Current projects focus on the role of dendritic nonlinearities in the prefrontal cortex and the animal's ability to exhibit behavioral flexibility. 
 

For more details on our experimental projects visit the links below:
 

NARSAD/ELIDEK & EINSTEIN

a

read more ...

Outreach

Συνενέντευξη της Δρ. Ποϊράζη στο protagon.gr σχετικά με την έρευνα που διεξάγεται στο εργαστήριο, με ειδικό αφιέρωμα στα αποτελέσματα της πρόσφατης συνεργασίας με το εργαστήριο του Dr. Losonczy στο Πανεπιστήμιο του Columbia.


Dr. Poirazi representing the European Research Council at World Economic Forum.

read more ...

Latest News

Feature selectivity in visual cortex: Our collaborative work with the Smirnakis lab is published in Nature Communications

Ever wondered how individual dendrites contribute to orientation tunings? Wonder no more. Check out our latest publication and see how neuronal modeling can guide / aid advanced new technologies in lab experimentation ...

read more ...

Deep Learning - New Perspective in Nature Neuroscience

Together with a group of amazing scientists, we recently wrote a Perspective on how Deep Learning principles may help advance Neuroscience and vise-versa. It started as heated discussions in a meeting in ...

read more ...

Our recent Nature Communications publication is featured by the editors

Challenging the point-neuron dogma is no easy feat, but hard work pays off! 

read more ...

Einstein Foundation Berlin has awarded Dr. Poirazi with the prestigious Einstein Visiting Fellowship ⭐

The fellowship is awarded to researchers from abroad whose scientific expertise can help ensure the leading edge of research institutes based in Berlin …

read more ...

Our latest take on neural computations of the brain is out now | Nature Communications

It’s been 16 years since Dr. Poirazi, head of the lab, got to publish her research on the nonlinear functions of pyramidal neurons; a theoretical prediction that, however prominent may be now, was against all odds and dogmas.

Despite its success, the concept has yet to escape the realm of excitatory neurons, leaving their inhibitory counterparts rather neglected ...

read more ...

IMBB-FORTH and Columbia University researchers pinpoint the neurons that control brain's memory flow

The laboratories of Dr. Losonczy at Columbia University in New York, and ours, Dr. Poirazi at the Institute of Molecular Biology and Biotechnology (IMBB) of FORTH, joined forces in order to explain how neurons flexibly lay down or recall memories. The study, which was recently published in Neuron, is the first to provide visual evidence that a particular ...

read more ...
see more news ...

Funding