Welcome to the Computational Biology Lab
Research in the CBL can be divided in two disciplines: (a) computational neuroscience, where we focus on the use of modeling techniques for characterizing the role of dendrites in learning and memory and (b) bioinformatics, where we focus on the development of methods and tools for analyzing and modeling biological data.
We are particularly interested in understanding how dendrites and their integrative properties contribute to learning and memory functions. Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks). We then use the models to study how the anatomical, biophysical and plasticity properties of dendrites contribute to memory functions.
We focus on developing computational methods and tools for (a) analyzing large-scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks. Our methodological approaches include (a) novel clustering and feature selection algorithms, (b) machine learning algorithms such as artificial neural networks, hidden Markov models etc.
The Cypriot President, Nicos Anastasiadis gives Dr. Poirazi the “Manolis Christofides” award in a Ceremony that took place in Nicosia on March 14, 2014. Via CretaLive.gr
On stage at TEDx Heraklion, 2014
In July 2014 we organize DENDRITES2014 , a scientific meeting dedicated to our favorite research topic! This is the FIRST conference organized in Greece in the DENDRITES field. We have...
Dr. Panayiota Poirazi, is giving a talk at TEDx Herakleion this February. Prismanews The event homepage.
Congratulations to Nestoras Karathanassis for successfully defending his PhD dissertation thesis “miRNAs and cancer. An experimental and Bioinformatics approach.” During the course of his PhD, Nestoras studied the role of miRNAs in...
Congratulations to our lab member Athanasia Papoutsi for successfully defending her PhD thesis ”Modeling approaches for analyzing persistent activity in the prefrontal cortex”. During her PhD candidacy, Dr. Papoutsi examined the...
In the journal of European Parliament “Parliament Magazine” (issue 381, 16 December 2013), which is dedicated to the Greek Presidency, there is a specific reference (p. 51) to the “dEMORY”...
Dr. Panayiota Poirazi, Principal Researcher of the Institute of Molecular Biology and Biotechnology (IMBB / FORTH) was promoted to a Research Director.
A Marie Curie Intra European Fellowship has been awarded to Pavlos Pavlidis. In the proposal entitled as “Evolution of gene regulatory networks by means of natural selection and genetic drift”,...