About our research

Computational Neuroscience

We are interested in understanding how dendrites and their integrative properties contribute to learning and memory functions. Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks). We then use the models to study how the anatomical, biophysical and plasticity properties of dendrites contribute to memory functions.

 

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Experimental Neuroscience

Our lab has recently expanded its research activities to include experiments in mice. Using head-fixed behavioral set-ups, in vivo imaging and electrophysiology, our primary goal is to probe dendritic contributions to neuronal and circuit computations as well as behavior. Current projects focus on the role of dendritic nonlinearities in the prefrontal cortex and the animal's ability to exhibit behavioral flexibility. 
 

For more details on our experimental projects visit the links below:
 

NARSAD/ELIDEK & EINSTEIN

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Outreach

Συνενέντευξη της Δρ. Ποϊράζη στο protagon.gr σχετικά με την έρευνα που διεξάγεται στο εργαστήριο, με ειδικό αφιέρωμα στα αποτελέσματα της πρόσφατης συνεργασίας με το εργαστήριο του Dr. Losonczy στο Πανεπιστήμιο του Columbia.


Dr. Poirazi representing the European Research Council at World Economic Forum.

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Latest News

New Perspective in Nature Neuroscience is out now!

Together with a group of amazing scientists, we recently wrote a Perspective on how Deep Learning principles may help advance Neuroscience and vise-versa. It started as heated discussions in a meeting in ...

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We're recruiting! A new post-doctoral position is available in our lab

We are looking for a talented and enthusiastic scientist to join forces with us in starting an exciting new project ...

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Our recent Nature Comm paper is featured by the editors

Challenging the point-neuron dogma is no easy feat, but hard work pays off! 

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Einstein Foundation Berlin has awarded Dr. Poirazi with the prestigious Einstein Visiting Fellowship ⭐

The fellowship is awarded to researchers from abroad whose scientific expertise can help ensure the leading edge of research institutes based in Berlin …

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Our latest take on neural computations of the brain is out now | Nature Communications

It’s been 16 years since Dr. Poirazi, head of the lab, got to publish her research on the nonlinear functions of pyramidal neurons; a theoretical prediction that, however prominent may be now, was against all odds and dogmas.

Despite its success, the concept has yet to escape the realm of excitatory neurons, leaving their inhibitory counterparts rather neglected ...

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IMBB-FORTH and Columbia University researchers pinpoint the neurons that control brain's memory flow

The laboratories of Dr. Losonczy at Columbia University in New York, and ours, Dr. Poirazi at the Institute of Molecular Biology and Biotechnology (IMBB) of FORTH, joined forces in order to explain how neurons flexibly lay down or recall memories. The study, which was recently published in Neuron, is the first to provide visual evidence that a particular ...

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Funding