Long-range cortical inputs drive local dendritic spikes in hippocampal pyramidal neurons

We are excited to share our latest study in collaboration with the lab of Jayeeta Basu at NYU. In this work we joined forces to study how the brain conveys important environmental cues like novelty and reward. Using dendritic electrophysiology, optogenetics and computational modeling we uncovered a disinhibitory microcircuit that gates dendritic spikes in CA1 pyramidal neurons driven by lateral EC inputs. These inputs are among the first to be affected in Alzheimer’s disease. This work is important as it provides the first evidence of a disinhibitory circuit that controls the sensory information processing in the hippocampus. This study is published in Cell Reports and you can read it here.