{"id":3212,"date":"2026-08-06T09:55:07","date_gmt":"2026-08-06T09:55:07","guid":{"rendered":"https:\/\/dendrites.gr\/?p=3212"},"modified":"2026-08-06T09:55:07","modified_gmt":"2026-08-06T09:55:07","slug":"new-paper-out-clustered-inputs-engage-dendritic-nonlinearities-and-calcium-signaling-to-support-efficient-place-field-formation-in-ca1-pyramidal-neurons","status":"publish","type":"post","link":"https:\/\/dendrites.gr\/?p=3212","title":{"rendered":"New paper out: Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons"},"content":{"rendered":"<div class=\"xdj266r x14z9mp xat24cr x1lziwak x1vvkbs x126k92a\">\n<div dir=\"auto\"><span class=\"html-span xexx8yu xyri2b x18d9i69 x1c1uobl x1hl2dhg x16tdsg8 x1vvkbs x3nfvp2 x1j61x8r x1fcty0u xdj266r xat24cr xm2jcoa x1mpyi22 xxymvpz xlup9mm x1kky2od\"><img loading=\"lazy\" decoding=\"async\" class=\"xz74otr x15mokao x1ga7v0g x16uus16 xbiv7yw\" src=\"\/wp-content\/uploads\/2026\/08\/1f4ef.png\" alt=\"\ud83d\udcef\" width=\"16\" height=\"16\" \/><\/span>Excited to share our latest paper, led by <span class=\"html-span xdj266r x14z9mp xat24cr x1lziwak xexx8yu xyri2b x18d9i69 x1c1uobl x1hl2dhg x16tdsg8 x1vvkbs\"><span class=\"xt0psk2\"><span class=\"xjp7ctv\">Simone Tasciotti<\/span><\/span><\/span> and supervised by Dr. <span class=\"html-span xdj266r x14z9mp xat24cr x1lziwak xexx8yu xyri2b x18d9i69 x1c1uobl x1hl2dhg x16tdsg8 x1vvkbs\"><span class=\"xt0psk2\"><span class=\"xjp7ctv\">Panayiota Poirazi<\/span><\/span><\/span> in collaboration with the Losonczy and Polleux labs, now published in Cell Reports!<\/div>\n<\/div>\n<div class=\"x14z9mp xat24cr x1lziwak x1vvkbs xtlvy1s x126k92a\">\n<div dir=\"auto\"><span class=\"html-span xexx8yu xyri2b x18d9i69 x1c1uobl x1hl2dhg x16tdsg8 x1vvkbs x3nfvp2 x1j61x8r x1fcty0u xdj266r xat24cr xm2jcoa x1mpyi22 xxymvpz xlup9mm x1kky2od\"><img loading=\"lazy\" decoding=\"async\" class=\"xz74otr x15mokao x1ga7v0g x16uus16 xbiv7yw\" src=\"\/wp-content\/uploads\/2026\/08\/1f5de.png\" alt=\"\ud83d\uddde\ufe0f\" width=\"16\" height=\"16\" \/><\/span>In this study, we explored how the topological distribution of synapses across CA1 pyramidal neurons shapes spatial selectivity. By combining in vivo mapping with detailed biophysical modeling, we found that excitatory synapses form structural clusters on terminal dendrites, enabling neurons to generate stable place fields while using about 13% fewer active synapses. These clustered inputs trigger localized dendritic nonlinearities and sustained calcium influx that cannot be replicated by dispersed arrangements, highlighting synaptic clustering as a key mechanism for efficient, compartmentalized computation in the hippocampus.<\/div>\n<\/div>\n<div class=\"x14z9mp xat24cr x1lziwak x1vvkbs xtlvy1s x126k92a\">\n<div dir=\"auto\">Read the full open-access paper here: <a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2026.117793\">https:\/\/doi.org\/10.1016\/j.celrep.2026.117793<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Excited to share our latest paper, led by Simone Tasciotti and supervised by Dr. Panayiota Poirazi in collaboration with the Losonczy and Polleux labs, now published in Cell Reports! In this study, we explored how the topological distribution of synapses across CA1 pyramidal neurons shapes spatial selectivity. By combining in vivo mapping with detailed biophysical [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":3213,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[16,1],"tags":[],"class_list":["post-3212","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-frontpagenews","category-news","post-with-thumbnail","post-with-thumbnail-large"],"_links":{"self":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts\/3212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3212"}],"version-history":[{"count":1,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts\/3212\/revisions"}],"predecessor-version":[{"id":3216,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts\/3212\/revisions\/3216"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/media\/3213"}],"wp:attachment":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}