{"id":2808,"date":"2025-06-12T06:32:13","date_gmt":"2025-06-12T06:32:13","guid":{"rendered":"https:\/\/dendrites.gr\/?p=2808"},"modified":"2025-06-12T06:32:13","modified_gmt":"2025-06-12T06:32:13","slug":"spontaneous-dynamics-predict-the-effects-of-targeted-intervention-in-hippocampal-neuronal-cultures","status":"publish","type":"post","link":"https:\/\/dendrites.gr\/?p=2808","title":{"rendered":"Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures"},"content":{"rendered":"<p>A\u00a0collaborative study between the\u00a0<strong>Vassanelli and Poirazi Labs<\/strong>\u00a0presented a new\u00a0method for understanding functional connectivity in neuronal cultures. The\u00a0study used\u00a0<strong>Interventional Connectivity (IC)\u00a0<\/strong>to probe neuronal activity in cultures grown\u00a0on High-Density Multi-Electrode Arrays (HD-MEAs) and revealed that the network&#8217;s causal architecture can be reliably predicted from its\u00a0<strong>spontaneous activity.<\/strong><\/p>\n<p>This approach offers a practical method for analyzing neuronal networks and designing targeted experiments in vitro. Read the full paper\u00a0<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.04.29.651327v1\">here<\/a>. The work was a result of the\u00a0<strong>NEUREKA\u00a0<\/strong>project.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A\u00a0collaborative study between the\u00a0Vassanelli and Poirazi Labs\u00a0presented a new\u00a0method for understanding functional connectivity in neuronal cultures. The\u00a0study used\u00a0Interventional Connectivity (IC)\u00a0to probe neuronal activity in cultures grown\u00a0on High-Density Multi-Electrode Arrays (HD-MEAs) and revealed that the network&#8217;s causal architecture can be reliably predicted from its\u00a0spontaneous activity. This approach offers a practical method for analyzing neuronal networks and [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":2809,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[14,16,1],"tags":[],"class_list":{"0":"post-2808","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","6":"hentry","7":"category-spotlight","8":"category-frontpagenews","9":"category-news","11":"post-with-thumbnail","12":"post-with-thumbnail-large"},"_links":{"self":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts\/2808","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2808"}],"version-history":[{"count":2,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts\/2808\/revisions"}],"predecessor-version":[{"id":2811,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts\/2808\/revisions\/2811"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/media\/2809"}],"wp:attachment":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2808"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2808"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2808"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}