{"id":2800,"date":"2025-06-02T13:44:29","date_gmt":"2025-06-02T13:44:29","guid":{"rendered":"https:\/\/dendrites.gr\/?p=2800"},"modified":"2025-06-02T14:06:47","modified_gmt":"2025-06-02T14:06:47","slug":"how-does-synaptic-organization-shape-place-fields-in-ca1-pyramidal-neurons","status":"publish","type":"post","link":"https:\/\/dendrites.gr\/?p=2800","title":{"rendered":"How does synaptic organization shape place fields in CA1 pyramidal neurons?"},"content":{"rendered":"<p>We&#8217;re excited to share our latest collaborative study with the Losonczy Lab and Polleux Lab, led by <span class=\"html-span xdj266r x11i5rnm xat24cr x1mh8g0r xexx8yu x4uap5 x18d9i69 xkhd6sd x1hl2dhg x16tdsg8 x1vvkbs\"><span class=\"xt0psk2\"><span class=\"xjp7ctv\">Simone Tasciotti<\/span><\/span><\/span>, that is now available on bioRxiv!<\/p>\n<p>\ud83d\udd0d In this work, we tackle a central question in neuroscience: <strong>how do hippocampal neurons become selective for specific spatial locations?<\/strong><\/p>\n<p>\ud83d\udccc Using <em>hyperdetailed<\/em> reconstructions of individual CA1 pyramidal neurons, we reveal how the <strong>spatial distribution and clustering of synapses<\/strong> shapes <strong>place field selectivity<\/strong>.<\/p>\n<p>\ud83d\udca1 Our computational models show:<\/p>\n<ul>\n<li>Co-tuned, spatially clustered excitatory inputs support robust spatial tuning \ud83e\udded<\/li>\n<li>Randomized synaptic arrangements disrupt tuning \ud83e\udde0\u274c<\/li>\n<li>Clustering has distinct effects on apical vs. basal dendrites \ud83c\udf3f<\/li>\n<\/ul>\n<p>These findings highlight the intricate relationship between synaptic architecture and neuronal computation in the hippocampus.<\/p>\n<p>\ud83d\udcc4 Read the full preprint <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.05.30.657022v1\">here<\/a>.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We&#8217;re excited to share our latest collaborative study with the Losonczy Lab and Polleux Lab, led by Simone Tasciotti, that is now available on bioRxiv! \ud83d\udd0d In this work, we tackle a central question in neuroscience: how do hippocampal neurons become selective for specific spatial locations? \ud83d\udccc Using hyperdetailed reconstructions of individual CA1 pyramidal neurons, [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":2801,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[14,16,1],"tags":[],"class_list":{"0":"post-2800","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","6":"hentry","7":"category-spotlight","8":"category-frontpagenews","9":"category-news","11":"post-with-thumbnail","12":"post-with-thumbnail-large"},"_links":{"self":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts\/2800","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2800"}],"version-history":[{"count":4,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts\/2800\/revisions"}],"predecessor-version":[{"id":2806,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/posts\/2800\/revisions\/2806"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=\/wp\/v2\/media\/2801"}],"wp:attachment":[{"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2800"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2800"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dendrites.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}